4 Reasons You Might Need Methylated B12
Most people are aware that B vitamins are good for you. You may even know that they help with energy, mood, nerve signaling, and a lot more. But when it comes to B12, also known as Cobalamin, things can get a bit tricky. Although there are several types of cobalamin, we’ll be focusing on the two most common forms: cyanocobalamin and methylcobalamin. Cyanocobalamin is a lab-made version, while methylcobalamin can be found in foods like salmon, egg yolks, meats, and cheese. The difference between them is pretty big.
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Cyanocobalamin has a cyanide molecule attached (thus, the cyano- in the name) and needs to go through extra steps in the body to become active, like methylcobalamin. After you take cyanocobalamin, enzymes remove the cyanide molecule and convert it into methylcobalamin. But not everyone can do this conversion efficiently. Methylcobalamin, on the other hand, is already active and can be used by the body without any extra steps. Want to guess which version of cobalamin most supplement manufacturers use? If you guess cyanocobalamin, you’re right! It is cheap to produce and helps pad profit margins, making supplement companies more money. Don’t get too bummed out — a few reputable supplement manufacturers use the methylated version.
So why is it important to have vitamin B12 in its methylated form? Here are a few key reasons:
Methylation reactions: Methylation is an important process where a methyl group (CH3) is transferred to different molecules in the body. It's involved in DNA synthesis, neurotransmitter production, hormone metabolism, and detoxification. Methylcobalamin helps with these processes by assisting in methyl group transfer.
Detoxification: Methylation is closely linked to the body's detoxification processes. It helps eliminate toxins like heavy metals, pollutants, and certain medications. Methylation reactions are part of detox pathways, like converting homocysteine to methionine, which is needed for making glutathione, an important antioxidant and detox molecule. Methylcobalamin supports these detox processes by aiding in methylation.
MTHFR gene polymorphism: Some people have a genetic variation called MTHFR gene polymorphism, which affects an enzyme called MTHFR. This enzyme converts folate into its active form, which is necessary for methylation. Methylcobalamin can directly interact with the MTHFR enzyme and help ensure enough active folate for methylation in individuals with this genetic variation.
Better absorption: Methylcobalamin is easily absorbed and utilized by the body. Unlike cyanocobalamin, which needs conversion, cells can use methylcobalamin right away for various processes, including methylation and detoxification. for people with MTHFR, the unusable cyanocobalamin can throw off blood tests, making it look like your B12 is high when in reality the usable form of B12 is actually very low.
It's important to note that while methylcobalamin is particularly beneficial for individuals with certain genetic variations or impaired methylation processes, determining the specific need for methylated B12 can be challenging without genetic testing or professional guidance. So, to cover all bases and ensure optimal utilization of vitamin B12, including its involvement in methylation and detoxification processes, choosing a supplement with methylcobalamin is a wise choice. This form of B12 offers enhanced bioavailability and can be readily used by the body. If you aren’t sure how much B12 is right for you, consulting a nutrition professional is a wise next step.